Iron ions are involved in the construction of hemoglobin, functionally necessary are a number of enzymes and biologically active substances. Iron metabolism is under strict control in ogranizma. Merits of strict regulation becomes apparent if considered state of pathological accumulation of iron in various organs called hemochromatosis.
Reasons for accumulation of iron in the system
Hemochromatosis can be congenital disease. In the liver produces a protein called hepcidin. He participates in the regulation of iron metabolism – how much iron is absorbed in the digestive system, how will be utilized and how much will be stored in the body.
Any defect in the gene for this protein regulation of iron metabolism is upset. Larger Qty of the metal is drawn into the bowel and therefore more accumulated in organs – liver, joints, pituitary, pancreas, heart, and skin. This process is chronic, lasts for years and destroys the normal structure of the affected tissues.
Hemochromatosis may accompany other diseases, with no observed genetic predisposition. For example, in hemolytic anemias continuous destruction of red blood cells can cause increased deposition of iron in the organs. In red blood cells contain hemoglobin, the composition of which participate iron ions.
In other cases, multiple blood transfusions also can charge the body with excess iron. Therefore, hemochromatosis is a general concept, as can be as self disease and concomitant condition of another pathological process or therapeutic procedure.
Early symptoms of hemochromatosis
Clinical manifestation of the disease, the process of accumulation of iron has continued years. Therefore, symptoms and organ uzhrezhdaniya occur most often after 30-40 years of age. Initial complaints are tiredness, drowsiness, joint pain, decreased libido, menstrual disorders.
Articular symptoms early symptoms and are found in more than half affected by hemochromatosis. Involved joints are the hands and feet. Arthritis is due to the increased deposition of iron on the joint surfaces, and cartilage breakdown. Changes can be detected by X-ray.
Characteristic of hemochromatosis is the effect on the pituitary. This is the main regulatory endocrine, located in the brain. Hormones produced in the pituitary gland, affect sexual function, thyroid and adrenal glands. When this brain cancer starts deposition of iron, its functions progressively begin to drop.
Decreased stimulation of the thyroid gland determines fatigue and sleepiness. Decreased libido, impotence and menstrual disorders are the expression of a weak activation of the gonads. Develops so-called. secondary hypogonadism in men and women.